Partenaires



Rechercher

Sur ce site

Sur le Web du CNRS


Accueil du site > Annuaire > Pascale Coric

Nom : Pascale Coric

Ingénieur d’étude INSERM

Tel : 01-53-73-96-87

Courriel : Pascale Coric

Recherche :

Etudes structurales de protéines virales par RMN et Modélisation Moléculaire

Parties Techniques

  • Maintenance de 2 spectromètres opérant à 400 Mhz et à 600Mhz en proton.
  • Formation des étudiants et des chimistes à l’utilisation du spectromètre 400 Mhz

Publications

  • 29) B.Gautier, M. Miteva, V. Goncalves, F. Huguenot, P. Coric, S. Bouaziz, B. Seijo, J.F. Gaucher, I. Broutin, C. Garbay, A. Lesnard, S. Rault, N. Inguimbert, B. O. Villoutreix and M. Vidal. " Targeting the Proangiogenic VEGF-VEGFR Protein-Protein Interface with Drug-like Compounds by In Silico and In Vitro Screening ". Chemistry & Biology, 2011, 18, 1631–1639.
  • 28) G. Gonzalez, S. Dafonseca, E. Errazuriz, P.Coric, F. Souquet, S. Turcaud, P. Boulanger, S. Bouaziz, S.S. Hong. "Characterization of a Novel Type of HIV-1 Particle Assembly Inhibitor Using a QuantitativeLuciferase-Vpr Packaging-Based Assay". PLoS One. 2011 ; 6 (11), 1-18.
  • 27) S. Dafonseca, P. Coric, B. Gay, S.S. Hong, S. Bouaziz and P. Boulanger. " The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3’,3’-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain". Virology Journal, 2008, 5, 1-18.
  • 26) V. Goncalves, B. Gautier, A. Regazetti, P. Coric, S. Bouaziz, C. Garbay, M. Vidal and N. Inguimbert.“On-resin cyclization of peptide ligands of the Vascular Endothelial Growth Factor Receptor 1 by copper(I)-catalyzed 1,3-dipolar azide–alkyne cycloaddition". Bioorg. Med. Chem. Lett., 2007, 17, 5590-5594.
  • 25) V. Goncalves, B. Gautier, P. Coric, S. Bouaziz, C. Lenoir, C. Garbay, M. Vidal and N. Inguimbert. "Rational Design, Structure, and Biological Evaluation of Cyclic Peptides Mimicking the Vascular Endothelial Growth Factor " . J. Med. Chem. , 2007, 50(21), 5135-5146.
  • 24) S. Dafonseca, A. Blommaert, P. Coric, S.S. Hong, S. Bouaziz and P. Boulanger. "The 3-O-(3’,3’-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells". Antiviral Therapy, 2007, 12, 1185-1203.
  • 23) N. Inguimbert, H. Dhotel, P. Coric and B.P. Roques. “Unexpected formation of new chiral 3-amino-5-alkyl-2,5-dihydro-1H-pyrrolin-2ones from N-Boc-alpha-amino esters “. Tet. Letters, 2005, 46, 3517-3520.
  • 22) N. Inguimbert, P. Coric, H. Dhotel, E. Bonnard, C. Llorens-Cortes, N. De Mota, M.C. Fournié-Zaluski , B.P. Roques. “Synthesis and in vitro activities of new non-peptidic APA inhibitors “. J. Pept. Res., 2005, 65, 175-188
  • 21) N. Inguimbert, P. Coric, H. Dhotel, C. Llorens-Cortes, M.C. Fournié-Zaluski and B.P. Roques. “Synthesis and separation of tritiated inhibitors of aminopeptidase A and their prodrugs”. J. Label. Compd. Radiopharm. 2004, 47 : 997-1005.
  • 20) N. Inguimbert, H. Dhotel, H. Poras, P. Coric, M.C. Fournié-Zaluski, B.P. Roques. “Vasopeptidases inhibitors of ACE, NEP an d ECE ”. PharmaChem July/August 2004, 3(7), 41-45.
  • 19) N. Inguimbert, P. Coric, H. Poras, H. Meudal, Franck Teffot, M.C.Fournié-Zaluski and B.P. Roques. "Toward an optimal joint recognition of the S1’ subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP)". J. Med. Chem. 2002, 45(7),1477-1486.
  • 18) H. Chen, F. Noble, A. Mothe, H. Meudal, P. Coric, S. Danascimento, B.P. Roques, P. George and M.C. Fournié Zaluski. “Phosphinic derivatives as new dual enkephalin degrading enzyme inhibitors : Synthesis, biological properties and antinociceptive activities“. J. Med. Chem. 2000, 43(7), 1398-1408.
  • 17) H. Chen, F. Noble, P. Coric, M.C. Fournié-Zaluski and B.P. Roques. "Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes : A class of central analgesics". Proc. Natl. Acad. Sci., 1998, 95(20), 12028-12033.
  • 16) L. Martin, F. Cornille, P. Coric, B.P. Roques and M.C. Fournié-Zaluski. "ß-aminothiols inhibit the Zn-metallopeptidase activity of tetanus toxin light chain". J. Med. Chem., 1998, 41(18), 3450-3460.
  • 15) F. Noble, C. Smadja, O. Valverde, R. Maldonado, P. Coric, S. Turcaud, M.C. Fournié-Zaluski and B.P. Roques. "Pain-Suppressive Effects On Various Nociceptive Stimuli (Thermal, Chemical Electrical And Inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor Rb 120". Pain, 1997, 73, 383-391.
  • 14) C. Smadja, F. Ruiz, P. Coric, M.C. Fournié-Zaluski, B.P. Roques , R. Maldonado. "CCK-B receptors in the limbic system modulate the antidepressant-like effects induced by endogenous enkephalins". Psychopharmacol., 1997, 132(2), 227-236.
  • 13) M.C. Fournié-Zaluski, P. Coric, V. Thery, W. Gonzalez, H. Meudal, S. Turcaud, J.B. Michel and B.P. Roques. "Design of orally active dual inhibitors of neutral endopeptidase (NEP) and angiotensin converting enzyme (ACE) with long duration of action ". J. Med. Chem., 1996, 39(13), 2594-2608.
  • 12) P. Coric, S. Turcaud, H. Meudal, B.P. Roques and M.C. Fournié-Zaluski. "Optimal recognition of neutral endopeptidase (NEP) and angiotensin converting enzyme(ACE) active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors". J. Med. Chem., 1996, 39(6), 1210-1219.
  • 11) F. Noble, P. Coric, S. Turcaud And B.P. Roques. "RB 101, mixed inhibitor prodrug of enkephalin-degrading enzymes, intravenously infused in rats does not induce development of physical dependence". Regulatory Peptides, "Towards a Molecular Basis in Opioid Research", Supp.1, Elsevier 1994, pp. S125-S126.
  • 10) M.C. Fournié-Zaluski, P. Coric, S. Turcaud, N. Rousselet, W. Gonzalez, B. Barbe, I. Pham, N. Jullian, J.B. Michel and B.P. Roques. "New dual inhibitors of neutral endopeptidase and angiotensin converting enzyme : rational design, bioavailability and pharmacological responses in experimental hypertension". J. Med. Chem., 1994, 37, 1070-1083.
  • 9) F. Noble, P. Coric, S. Turcaud, M.C. Fournié-Zaluski , B.P. Roques. "Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101". Eur. J. Pharm., 1994, 253, 283-287.
  • 8) O. Valverde, P. Coric, B.P. Roques and R. Maldonado. "Antinociception induced by exogenous and endogenous opioids : role of different brain structures". Regulatory Peptide, 1994, 54(1), 309-310.
  • 7) E.N. Chauvel, C. Llorens-Cortès, P. Coric, S. Wilk, B.P. Roques and M.C. Fournié-Zaluski. "Differential Inhibition of aminopeptidase A and aminopeptidase N by -new Beta-amino thiols". J. Med. Chem., 1994, 37(18), 2950-2957.
  • 6) E.N. Chauvel, P. Coric, C. Llorens-Cortès, S. Wilk, B.P. Roques and M.C. Fournié-Zaluski. "Investigation of the active site of aminopeptidase A using a series of- new thiol-containing inhibitors".J. Med. Chem., 1994, 37(9), 1339-1346.
  • 5) M.C. Fournié-Zaluski, P. Coric, S. Turcaud, L. Bruetschy, E. Lucas, F. Noble and B.P. Roques. "Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation". J. Med. Chem., 1992, 35(7),1259-1266.
  • 4) M.C. Fournié-Zaluski, P. Coric, S. Turcaud, E. Lucas, F. Noble, R. Maldonado and B.P. Roques. "Mixed-inhibitor-prodrug as a new approach toward systemically active inhibitors of enkephalin degrading enzymes". J. Med. Chem., 1992, 35(13), 2474-2481.
  • 3) F. Noble, P. Coric, M.C. Fournié-Zaluski and B.P. Roques. "Lack of physical dependence development in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB 101". Eur. J. Pharmacol., 1992, 223, 91-96.
  • 2) B.P. Roques, G. Gacel,V. Daugé, A. Baamonde, G. Calenco, S. Turcaud, P. Coric, M.C. Fournié-Zaluski. "Novel approaches in the development of new analgesics". Neurophysiol Clin. 1990, 20, 369-387.
  • 1) Roques, B.R., Coric, P., Noble, F., Maldonado, R., Delay-Goyet, P., Popovici, T. and Fournié-Zaluski, M.C. " Extensive biochemical and pharmacological studies of the first systemically-active, mixed inhibitors of enkephalin-degrading enzymes". Eur. J. Pharmacol.,1990, 183, 6, 2315-2316.

Brevets

Extension of the European patent application No. 11306138.6 to the U.S. for "Novel inhibitors of assembly and maturation of HIV" S. Bouaziz ; P. Boulanger ; L. Briant ; N. Chazal ; P. Coric ; SS Hong ; F. Souquet ; S.Turcaud (2012).

Brevet EP11306138 à l’Office européen des brevets. "DERIVATIVES OF 3-O-(3’,3’DIMETHYLSUCCINYL)-BETULINIC ACID" S. Bouaziz ; P. Boulanger ; L. Briant ; N. Chazal ; P. Coric ; SS Hong ; F. Souquet ; S. Turcaud (2011).