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Accueil du site > Annuaire > Simon Lebaron

Nom : Simon Lebaron

Chargé de Recherche INSERM

Tel : 01-53-73-15-70

Courriel : Simon Lebaron

Recherche :
- Biogenèse des ribosomes
- Hélicases à ARN
- Endonucéases

Spécialités :
- Etude fonctionnelle chez la levure
- Biochimie sur les particules ribonucléoprotéiques
- Maturation in vitro

Publications

1. Lebaron S, Segerstolpe A, French S, Dudnakova T, De Lima Alvas F, Granneman S, Rappsilber J, Beyer A, Wieslander L, Tollervey D. Rrp5 binding at multiple sites coordinates pre-rRNA processing and assembly. Molecular Cell 2013, In press

2. Sloan KE, Mattijsen S, Lebaron S, Tollervey D, Pruijn JM, Watkins NJ. Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human rRNA processing. JCB 2012 in press.

3. Lebaron S, Schneider C, van Nues RW, Swiatkowska A, Walsh D, Böttcher B, Granneman S, Watkins NJ, Tollervey D. Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits. Nat Struct Mol Biol. 2012 Jul 1 ;19(8):744-53.

4. García-Gómez JJ, Lebaron S, Froment C, Monsarrat B, Henry Y, de la Cruz J. Dynamics of the Putative RNA Helicase Spb4 during Ribosome Assembly in Saccharomyces cerevisiae. Mol Cell Biol. 2011 Oct ;31(20):4156-64. Epub 2011 Aug 8.

5. Juan José García-Gómez, Reyes Babiano, Simon Lebaron, Carine Froment, Bernard Monsarrat, Yves Henry and Jesús de la Cruz. Nop6, a component of 90S pre-ribosomal particles, is required for 40S ribosomal subunit biogenesis in Saccharomyces cerevisiae. RNA Biology Volume 8 Issue 1, 2011.

6. Walbott H, Mouffok S, Capeyrou R, Lebaron S, Humbert O, van Tilbeurgh H, Henry Y, Leulliot N. Prp43p contains a processive helicase structural architecture with a specific regulatory domain. EMBO J. 2010 Jul 7 ;29(13):2194-204. Epub 2010 May 28.

7. Lebaron S, Papin C, Capeyrou R, Chen YL, Froment C, Monsarrat B, Caizergues-Ferrer M, Grigoriev M, Henry Y. The ATPase and helicase activities of Prp43p are stimulated by the G-patch protein Pfa1p during yeast ribosome biogenesis. EMBO J. 2009 Dec 16 ;28(24):3808-19.

8. Henras AK, Soudet J, Gérus M, Lebaron S, Caizergues-Ferrer M, Mougin A, Henry Y. The post-transcriptional steps of eukaryotic ribosome biogenesis. Cell Mol Life Sci. 2008 Aug ;65(15):2334-59. Review.

9. Rosado IV, Dez C, Lebaron S, Caizergues-Ferrer M, Henry Y, de la Cruz J. Characterization of Saccharomyces cerevisiae Npa2p (Urb2p) reveals a low-molecular-mass complex containing Dbp6p, Npa1p (Urb1p), Nop8p and Rsa3p involved in early steps of 60S ribosomal subunit biogenesis. Mol Cell Biol. 2007 Feb ;27(4):1207-21. Epub 2006 Dec 4.

10. Lebaron S, Froment C, Fromont-Racine M, Rain JC, Monsarrat B, Caizergues-Ferrer M, Henry Y. The splicing ATPase Prp43p is a component of multiple preribosomal particles. Mol Cell Biol. 2005 Nov ;25(21):9269-82