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Nom : Marie-Bernard Lascombe

Chargée de Recherche CNRS

- Assistante de Prévention du Laboratoire de Cristallographie et RMN Biologiques





- Recherche :

  • Etude structurale du système Prolactine/Récepteur à la Prolactine et des protéines associéescomplex, and some associated proteins.
  • Signalisation cellulaire
  • Cristallogenese
  • Cristallographie aux Rayons-X

- Publications

  • Phan, G., Benabdelhak, H., Lascombe, M. B., Benas, P., Rety, S., Picard, M., Ducruix, A., Etchebest, C. and Broutin, I. (2010), Structural and dynamical insights into the opening mechanism of P. aeruginosa OprM channel, Structure, 18, 507-17.
  • Bakan, B., Hamberg, M., Larue, V., Prange, T., Marion, D. and Lascombe, M. B. (2009), The crystal structure of oxylipin-conjugated barley LTP1 highlights the unique plasticity of the hydrophobic cavity of these plant lipid-binding proteins, Biochem Biophys Res Commun 390, 780-5.
  • Lascombe, M. B., Bakan, B., Buhot, N., Marion, D., Blein, J. P., Larue, V., Lamb, C., and Prange, T. (2008), The Structure of "Defective in Induced Resistance" Protein of Arabidopsis Thaliana, Dir1, Reveals a New Type of Lipid Transfer Protein, Protein Sci., 17, 1522-1530.
  • Phan G, B. I., Lascombe M, Benas P, Ducruix A (2007), Structural study of a potential therapeutic target : the antibiotics efflux pump MexXY-OprM from Pseudomonas aeruginosa, FEBS Journal 274, 341-378.
  • Lascombe, M. B., Retailleau, P., Ponchet, M., Industri, B., Blein, J. P., and Prange, T. (2007), Structure of sylvaticin, a new alpha-elicitin-like protein from Pythium sylvaticum, Acta Crystallogr D Biol Crystallogr 63, 1102-1108.
  • Lascombe, M. B., Buhot, N., Bakan, B., Marion, D., Blein, J. P., Lamb, C. J., and Prange, T. (2006), Crystallization of DIR1, a LTP2-like resistance signalling protein from Arabidopsis thaliana, Acta Crystallograph Sect F Struct Biol Cryst Commun 62, 702-704.
  • Broutin, I., Benabdelhak, H., Moreel, X., Lascombe, M. B., Lerouge, D., and Ducruix, A. (2005), Expression, purification, crystallization and preliminary X-ray studies of the outer membrane efflux proteins OprM and OprN from Pseudomonas aeruginosa, Acta Crystallographica Section F-Structural Biology and Crystallization Communications 61, 315-318.
  • Lascombe, M. B., Ponchet, M., Cardin, L., Milat, M. L., Blein, J. P., and Prange, T. (2004), Purification, crystallization and preliminary X-ray studies of sylvaticin, an elicitin-like protein from Pythium sylvaticum, Acta Crystallogr D Biol Crystallogr 60, 362-364.
  • Lascombe, M. B., Ponchet, M., Venard, P., Milat, M. L., Blein, J. P., and Prange, T. (2002), The 1.45 A resolution structure of the cryptogein-cholesterol complex : a close-up view of a sterol carrier protein (SCP) active site, Acta Crystallogr D Biol Crystallogr 58, 1442-1447.
  • Guerin, D. M., Lascombe, M. B., Costabel, M., Souchon, H., Lamzin, V., Beguin, P., and Alzari, P. M. (2002), Atomic (0.94A) Resolution Structure of an Inverting Glycosidase in Complex with Substrate, J Mol Biol 316, 1061-1069.
  • Lascombe, M. B., Gregoire, C., Poncet, P., Tavares, G. A., Rosinski-Chupin, I., Rabillon, J., Goubran-Botros, H., Mazie, J. C., David, B., and Alzari, P. M. (2000), Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes, Journal of Biological Chemistry 275, 21572-21577.
  • Lascombe, M. B., Milat, M. L., Blein, J. P., Panabieres, F., Ponchet, M., and Prange, T. (2000). Crystallization and preliminary X-ray studies of oligandrin, a sterol-carrier elicitor from Pythium oligandrum, Acta Crystallographica Section D-Biological Crystallography 56, 1498-1500.