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Valéry Larue

Ingénieur de Recherche - CNRS

Tel : 01-53-73-15-72

Courriel : Valery Larue

Recherche :
- Etude struturale de nouvelles cibles antiinfectieuses
- Spectroscopie RMN des ARNs et des protéines
- Criblage RMN
- Bioinformatique

Parties Techniques
- Responsable plateforme RMN
- Modéliation moléculaire
- Webmaster
- AE - certificats CNRS

Publications sélectionnées

(30) - Dégut C, Roovers M, Barraud P, Brachet F, Feller A, Larue V, Al Refaii A, Caillet J, Droogmans L, Tisné C. Structural characterization of B. subtilis m1A22 tRNA methyltransferase TrmK : insights into tRNA recognition. Nucleic Acids Res. 2019 Apr 1. doi : 10.1093/nar/gkz230.

(29) - Mouhand A, Belfetmi A, Catala M, Larue V, Zargarian L, Brachet F, Gorelick RJ, Van Heijenoort C, Mirambeau G, Barraud P, Mauffret O, Tisné C. Modulation of the HIV nucleocapsid dynamics finely tunes its RNA-binding properties during virion genesis. Nucleic Acids Res. 2018 Oct 12 ;46(18):9699-9710.

(28) - El Meshri SE, Boutant E, Mouhand A, Thomas A, Larue V, Richert L, Vivet-Boudou V, Mély Y, Tisné C, Muriaux D, de Rocquigny H. The NC domain of HIV-1 Gag contributes to the interaction of Gag with TSG101.Biochim Biophys Acta. 2018 Mar 20 ;1862(6):1421-1431.

(27) - Larue V, Catala M, Belfetmi A, Zargarian L, Mauffret O, Tisné C. 1H, 13C and 15N backbone and partial side-chain resonance assignments of the C-terminal domain of HIV-1 Pr55Gag encompassed in NCp15. Biomol NMR Assign. 2018 Jan 13. doi : 10.1007/s12104-017-9796-x.

(26) - Dégut C, Barraud P, Larue V, Tisné C. Backbone resonance assignments of the m1A22 tRNA methyltransferase TrmK from Bacillus subtilis. Biomol NMR Assign. 2016 Oct ;10(2):253-7.

(25) - Sleiman D, Bernacchi S, Xavier Guerrero S, Brachet F, Larue V, Paillart JC, Tisne C. Characterization of RNA binding and chaperoning activities of HIV-1 Vif protein : Importance of the C-terminal unstructured tail. RNA Biol. 2014 Jul 1 ;11(7):906-20.

(24) - Piton J, Larue V, Thillier Y, Dorléans A, Pellegrini O, Li de la Sierra-Gallay I, Vasseur JJ, Debart F, Tisné C, Condon C.Bacillus subtilis RNA deprotection enzyme RppH recognizes guanosine in the second position of its substrates. Proc Natl Acad Sci U S A. 2013, May 28, 110, 22 : 8858-8863.

(23) - Lombès T, Moumné R, Larue V, Prost E, Catala M, Lecourt T, Dardel F, Micouin L, Tisné C, Investigation of RNA-ligand interaction by 19F NMR spectroscopy using fluorinated probes. Angewandte Chemie Int. Ed. Engl. 2012 ; 51(38):9530-4.

(22) - Goemaere E, Melet A, Larue V, Lieutaud A, Alves de Sousa R, Chevalier J, Yimga-Djapa L, Giglione C, Huguet F, Alimi M, Meinnel T, Dardel F, Artaud I, Pagès JM. New peptide deformylase inhibitors and cooperative interaction : a combination to improve antibacterial activity. J Antimicrob Chemother. 2012 67, 1392-1400.

(21) - Moumné R, Catala M, Larue V, Micouin L, Tisné C. Fragment-based design of small RNA binders : promising developments and contribution of NMR. Biochimie. 2012 ;94(7):1607-19.

(20) - Moumné R, Larue V, Seijo B, Lecourt T, Micouin L, Tisné C. Tether influence on the binding properties of tRNA(Lys)(3) ligands designed by a fragment-based approach. Org Biomol Chem. 2010 Mar 7 ;8(5):1154-9.

(19) - Bakan B, Hamberg M, Larue V, Prangé T, Marion D, Lascombe MB. The crystal structure of oxylipin-conjugated barley LTP1 highlights the unique plasticity of the hydrophobic cavity of these plant lipid-binding proteins. Biochem Biophys Res Commun. 2009 ;390(3):780-5.

(18) - Larue V., Seijo, B., Tisné, C., and Dardel, F. H-1, C-13 and N-15 NMR assignments of the E. coli peptide deformylase in complex with a natural inhibitor called actinonin, Biomolecular NMR Assignments. 2009 ; 3 : 153-155.

(17) - Petit S, Duroc Y, Larue V, Giglione C, Léon C, Soulama C, Denis A, Dardel F, Meinnel T, Artaud I Structure-Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5-bromo-1H-indole-3-ace-tohydroxamic acid. ChemMedChem 2009 ; 2 : 261-275.

(16) - Lascombe, M. B., Bakan, B., Buhot, N., Marion, D., Blein, J. P., Larue, V., Lamb, C., and Prange, T. . The Structure of "Defective in Induced Resistance" Protein of Arabidopsis Thaliana, Dir1, Reveals a New Type of Lipid Transfer. Protein. Protein Sci, 2008 ;17(9):1522-30

(15) - Adrien Boularot, Carmela Giglione, Sylvain Petit, Yann Duroc, Rodolphe Alves de Sousa, Valéry Larue, Thierry Cresteil, Frédéric Dardel, Isabelle Artaud and Thierry MeinnelDiscovery and Refinement of a New Structural Class of Potent Peptide Deformylase Inhibitors. J. Med. Chem, 2007, 50, 10-20.

(14) - Moncoq K, Broutin I,Larue V, Perdereau D, Cailliau K, Browaeys-Poly E, Burnol AF, Ducruix A. The PIR domain of Grb14 is an intrinsically unstructured protein : implication in insulin signaling. FEBS Lett. 2003, 554 (3), 240-6.

(13) - Le Moyec L, Racine S, Le Toumelin P, Adnet F,Larue V, Cohen Y, Leroux Y, Cupa M, Hantz E. Aminoglycoside and glycopeptide renal toxicity in intensive care patients studied by proton magnetic resonance spectroscopy of urine. Crit Care Med, 2002, 30 (6), 1242-5.

(12) - Edith Hantz, Valery Larue, Patrick Ladam, Laurence Le Moyec, Catherine Gouyette, Tam Huynh Dinh. Solution Conformation of an RNA-DNA hybrid duplex containing a pyrimidine RNA strand and a purine DNA strand. International Journal of Biological Macromolecules, 2001, 28 (4), 273-84.

(11) - Ramon Bargada, Theodorine Bailly, Marc Lecouvey, Valery Larue, Yves Leroux. Synthesis of New Phosphonated Tripod Ligands as Putative New Therapeutics Agents in the Chelation Treatment of Metal. European Journal of Organic Chemistry, 2001 2, 349-352.

(10) - Le Moyec L., Kawakami M., Leray G.,Larue V., Briane D., Hantz E. and de Certaines J. Magnetic resonance spectroscopy and fluorescence microscopy to investigate mobile lipids in sensitive, resistant and reverting K562 cells and their membranes. Anticancer Research, 2000 20 (6B), 4513-8.

(9) - Le Moyec L, Legrand O,Larue V, Kawakami M, Marie JP, Calvo F, Hantz E, Taillandier E. Current Awareness. NMR In Biomedicine, 2000, 13 (2), 102-107.

(8) - L. Le Moyec, O. Legrand, V. Larue, M. Kawakami, J. P. Marie, F. Calvo, E. Hantz, E. Taillandier. Spectroscopy of cellular Lipid extracts from sensitive, resistant and reverting K562 cells and Flow cytometry for investigating the P-glycoprotein function in resistance reversion. NMR In Biomedicine, 2000,13 (2), 92-101.

(7) - Nathalie Evrard-Todeschi, Josyane Gharbi-Benarous, Valéry Larue, Jean-Pierre Girault. A Predictive study by Molecular Modelling to promote specific probes of Glutamate Receptors, using methylated Cyclic Glutamic acid derivatives (trans- and cis- ACPD). Comparison with Specific Agonists. Journal of Chemical Information and Computer Sciences, 1998, 38 (4):742-60.

(6) - N. Todeschi, J. Gharbi-Benarous, F. Acher, V. Larue, R. Azerad , J.-P. Girault . Conformational analysis by NMR spectroscopy and molecular simulation in water of methylated glutamic acids, agonists at glutamate receptors. Biorganic and Medicinal Chemistry, 1997, 5 (2), 335-352.

(5) - Valéry Larue, Josyane Gharbi-Benarous, Francine Acher, Veerappan Arulmozhi, Carine Tisné, Nathalie Todeschi, Robert Azerad, Jean-Pierre Girault. Solution Conformation of a, b or g-Methylglutamyl-Containing Derivatives as Probes of Carboxylase Vitamin K Dependent using Molecular Modelling and Nuclear Magnetic Resonance. International Journal of Biological Macromolecules, 1997, 20 (2), 131-159.

(4) - V. Larue, J. Gharbi-Benarous, F. Acher, R. Azerad , J.-P. Girault. Vitamin K Dependent Carboxylase - In Vitro Inhibitory Activity of Cyclopentane and Cyclohexane-derived Analogues of Glutamic Acid and their Conformational Study by NMR and Molecular Dynamics in Aqueous Solution. Journal of Peptide Research, 1997, 49 (1) 28-45.

(3) - V. Larue, J. Gharbi-Benarous, F. Acher, R. Azerad, J.-P. Girault. Conformational Study in water by NMR and Molecular Modelling of Cyclic Glutamic Acid Analogues as probes of Vitamin K Dependent Carboxylase. Journal of Chemical Information and Computer Sciences, 1996, 36 (4), 717-725.

(2) - V. Larue, J. Gharbi-Benarous, N. Todeschi, F. Acher, R. Azerad, J-P. Girault. ACPD ligands for glutamic receptors : Conformational Analysis by NMR Spectroscopy and Molecular Dynamics Simulation in Water of Glutamic Acid Analogues containing a cyclopentane ring. Journal de Chimie Physique, 1995, 92, 1809-1812.

(1) - V. Larue, J. Gharbi Benarous, F. Acher, G. Valle, M. Crisma, C. Toniolo, R. Azerad, J.P. Girault. Conformational Analysis by NMR Spectroscopy, Molecular Dynamics Simulation in Water and X-Ray Crystallography of Glutamic Acid Analogues : Isomers of 1-Amino -1,3 Cyclopentane Dicarboxylic Acid (ACPD). Journal of Chemical Society, Perkin Trans 2, 1995, 1111-1126.